Fen-Phen e-Resource

What Is Primary Pulmonary Hypertension (PPH)?

Primary pulmonary hypertension (PPH) is a rare disease that results in the progressive narrowing of the blood vessels of the lungs, which as a result causes high blood pressure in these blood vessels and eventually leads to heart failure.

Heart Valve Surgery

Heart valve surgery has actually become a very common practice, and may be necessary for a variety of reasons. There are several things that can cause problems with your heart valves that can lead to heart valve surgery. Things that lead to the failure of a heart valve include mild defects at birth, diseases like rheumatic fever or bacterial infections may scar or destroy the valve, and aging and normal wear and tear of tissues will weaken or harden heart valves.

What Is Heart Valve Regurgitation?

The two most common heart valve disorders are aortic valve regurgitation and mitral valve regurgitation. Aortic valve regurgitation and mitral regurgitation (MR) occur when the aortic and mitral valves are damaged or not working properly.

Medical PDF Files

Aminorex to Fen/Phen - An Epidemic Foretold - by Alred P. Fishman, MD

Aminorex to Fen/Phen - An Epidemic Foretold - Arguments by Philippe Tellier, MD

Response: Aminorex to Fen/Phen - An Epidemic Foretold - Response to arguments by Alred P. Fishman, MD

Cardiac Valvulopathy Associated with Exposure to Fenfluramine or Dexfenfluramine

U.S. Department of Health and Human Services Interim Public Health Recommendations:
Fenfluramine and dexfenfluramine are appetite suppressants that were in widespread use in the United States. On July 8, 1997, 24 cases of valvular heart disease in women who had been treated with fenfluramine and phentermine were publicly reported [1] .

Primary Pulmonary Hypertension

Pulmonary hypertension occurs when blood circulation through your lungs is restricted by narrowed blood vessels. To maintain blood flow through these narrowed blood vessels, pulmonary artery pressure increases. Pulmonary hypertension can occur by itself, but is often caused by an existing disease. It is a rare condition that mostly affects women in their 30s or 40s.

The Natural History of Fenfluramine-Associated Valvulopathy Assessed by Echocardiography

Citation: Supplement to Journal of the American College of Cardiology February 2000, Vol. 35, Issue 2, Suppl. A, page 523

Steven T. Mast, James G. Jollis, Thomas Ryan, Carolyn K. Landolfo, Jack L. Crary

The HyperGEN Study

Relation of Mitral and/or Aortic Insufficiency to Body Size and Myocardial Energy Expenditure in Hypertensive Adults

Citation: Supplement to Journal of the American College of Cardiology February 2000, Vol. 35, Issue 2, Suppl. A, page 332

Dexfenfluramine Associated With Increased Aortic Valve Regurgitation

Dexfenfluramine use is accompanied by an increased prevalence of aortic valve regurgitation, but the valvular abnormalities may resolve with drug discontinuation, according to a report in the November 23rd issue of Circulation: Journal of the American Heart Association.

Phentermine Dismissed From Massachusetts 'Fen-phen' Case

Dismissal follows Judge's ruling that expert witnesses failed to present sufficient evidence that phentermine causes pulmonary hypertension

A former manufacturer of phentermine, one of the two drugs in the "fen-phen" combination, has been dismissed from a wrongful death case that is scheduled to go to trial in January in Cambridge, Massachusetts.